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Search Results for " histone deacetylase 8 "

Targets Recommended: HDAC

14

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3193	Pimelic diphenylamide 106 Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Pimelic diphenylamide 106 (RGFA-8) 是一种缓慢和紧密结合的I 类HDAC 抑制剂，对HDAC1、 2和3的IC50值分别150、760和370 nM。
T3206	NKL 22 Histone Deacetylase Inhibitor IV,PAOA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	NKL 22 (Histone Deacetylase Inhibitor IV) 是一种有效的选择性组蛋白脱乙酰基酶(HDAC) 抑制剂，对 HDAC2/4/5/7/8 具有选择性，抑制HDAC1和HDAC3的IC50值分别为 199 和 69 nM。它可改善亨廷顿氏病转基因小鼠的疾病表型和转录异常。
T73515	MC2590	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	MC2590 是一种具有有效性和选择性的组蛋白脱乙酰酶 (HDAC) 抑制剂，抑制 HDAC1-3、-6、-8 和 -10 的活性，诱导细胞周期停滞，促进细胞凋亡。
T30579	BRD4097	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BRD4097是HDAC1/2/3/8检测中的阴性对照品,是一种选择性组蛋白去乙酰化酶（HDAC3）抑制剂，可用于保护b 细胞和改善胰岛素抵抗，有助于促进认知功能和增强学习和记忆的形成。
T27648	J1075 J 1075,J-1075
	J1075 is an histone deacetylase 8 (HDAC8) inhibitor.
T27644	J1037 J 1037,J-1037
	J1037 is a novel Histone Deacetylase 8 (HDAC8) inhibitor .
T27645	J1038 J-1038,J 1038
	J1038 is a novel Histone Deacetylase 8 (HDAC8) Inhibitor .
T16270	Nanatinostat CHR-3996	Others	Others
	Nanatinostat is an effective and class I selective inhibitor of histone deacetylase (IC50: 8 nM).
T61549	HDAC8-IN-2
	HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 μM and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. It effectively kills schistosome larvae and greatly reduces egg laying in adult worm pairs [1].
T75021	SZUH280
	SZUH280 是一种有效的、选择性的 PROTACHDAC8降解剂，在 A549 细胞中的 DC50为 0.58 μM。SZUH280 诱导癌细胞凋亡 (apoptosis)。SZUH280 在癌细胞中阻碍 DNA 损伤修复，促进细胞放射致敏。
T37068	NR-160
	NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
T35762	MC1742
	MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...
T38381	CAY17c
	CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620,...

化合物

Pimelic diphenylamide 106

Cat.No: T3193

Synonym: Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8

Target: HDAC

Cat.No: T3206

Synonym: Histone Deacetylase Inhibitor IV,PAOA

Target: HDAC

Cat.No: T73515

Target: Apoptosis, HDAC

Cat.No: T30579

Target: HDAC

Cat.No: T27648

Synonym: J 1075,J-1075

Cat.No: T27644

Synonym: J 1037,J-1037

Cat.No: T27645

Synonym: J-1038,J 1038

Cat.No: T16270

Synonym: CHR-3996

Target: Others

Cat.No: T61549

Cat.No: T75021

Cat.No: T37068

Cat.No: T35762

Cat.No: T36629

Cat.No: T38381

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01333	HDAC8 Protein, Human, Recombinant (GST) histone deacetylase 8,CDA07,MRXS6...	Human	Baculovirus Insect Cells
	HDAC8 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68 kDa and the accession number is Q9BY41-1.
TMPY-02317	HDAC8 Protein, Mouse, Recombinant (His) histone deacetylase 8,2610007D20R...	Mouse	Baculovirus Insect Cells
	HDAC8 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 43.1 kDa and the accession number is Q8VH37-1.
TMPY-04123	CEACAM1 Protein, Human, Recombinant (His & hFc) CEACAM‑1,carcinoembryonic antigen-related cell adhesion mole...	Human	HEK293 Cells
	CEACAM1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 71.4 kDa and the accession number is P13688-8.
TMPH-01705	Mucin-1/MUC1 Protein, Human, Recombinant (His)	Human	E. coli
	Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8.
TMPJ-00808	CD45RA Protein, Human, Recombinant (His) PTPRC,CD45R,CD45,LCA,protein tyrosine phosphatase, receptor ...	Human	HEK293 Cells
	CD45RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-135 KDa and the accession number is P08575-8.
TMPJ-00828	Tau-F Protein, Human, Recombinant Neurofibrillary tangle protein,Paired helical filament-tau,M...	Human	E. coli
	Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are def...
TMPY-00717	CEACAM1 Protein, Human, Recombinant (His) CEACAM‑1,BGP1,BGP,carcinoembryonic antigen-related cell adhe...	Human	HEK293 Cells
	CEACAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.8 kDa and the accession number is P13688-8.
TMPY-06707	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) ADMCKD,PEMT,KL-6,ADMCKD1,H23AG,mucin 1, cell surface associa...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.49 kDa and the accession number is P15941-8.
TMPJ-01330	CD299 Protein, Human, Recombinant (His & Flag) DC-SIGNR,L-SIGN,CD299,CD209L,LSIGN,C-type lectin domain fami...	Human	HEK293 Cells
	CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysoso...
TMPY-00668	APP/Protease nexin-II Protein, Human, Recombinant (hFc) CTFγ,amyloid beta (A4) precursor protein,AAA,ABPP,CVAP,APPI,...	Human	HEK293 Cells
	APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8.

重组蛋白

HDAC8 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01333

Species: Human

Expression System: Baculovirus Insect Cells

HDAC8 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02317

Species: Mouse

Expression System: Baculovirus Insect Cells

CEACAM1 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-04123

Species: Human

Expression System: HEK293 Cells

Mucin-1/MUC1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01705

Species: Human

Expression System: E. coli

CD45RA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00808

Species: Human

Expression System: HEK293 Cells

Tau-F Protein, Human, Recombinant

Cat.No: TMPJ-00828

Species: Human

Expression System: E. coli

CEACAM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00717

Species: Human

Expression System: HEK293 Cells

Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His)

Cat.No: TMPY-06707

Species: Human

Expression System: HEK293 Cells

CD299 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-01330

Species: Human

Expression System: HEK293 Cells

APP/Protease nexin-II Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00668

Species: Human

Expression System: HEK293 Cells

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